Hence, we become susceptible to various age-related diseases, including cardiovascular and neurodegenerative disease, diabetes, various cancers, etc. It weakens our immune system, and most body systems lose structural and functional integrity. Aging is a complex, slow, and deleterious process that happens at molecular, cellular, and tissue levels throughout our body. Our increased aging population presents new medical challenges, due to age-related medical co-morbidities. Specifically in the US, the number of people above 65 is projected to expand from 52 million in 2018 to 95 million in 2060, with the proportion of those 65 years and older increasing from 16% to 23% of our population. Our population continues to grow older because of improved public health and medical care. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)-the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population-and inflammaging has gained interest. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. The slow accumulation of inflammatory biomarker levels in the body-also known as inflammaging-has been linked to a myriad of age-related diseases.
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